Ashwagandha can be taken with multivitamins
Ashwagandha has been used in Indian medicine for 5000 years to strengthen the life force. It is said to give inner calm and strength, reduce anxiety, increase energy, vitality and performance, act as a natural aphrodisiac, rejuvenate body and mind and promote longevity.
Ashwagandha (Withania somnifera) is a medicinal plant of the Indian medicine Ayurveda. Ashwagandha is also known as sleeping berry, Indian ginseng or winter cherry. It is a plant of the nightshade family (Solanaceae).  
Ashwagandha is also called "Indian ginseng", which is used in India in the same way as ginseng is used in traditional Chinese medicine to treat a wide range of ailments in humans.
In Ayurveda, ashwagandha is considered a "rasayana" herb, a remedy that works in a non-specific and comprehensive manner and promotes health and longevity. 
It is also considered an "adaptogen", a natural remedy that normalizes physiological functions caused by chronic stress by compensating for an imbalance in the hormonal and immune systems.
Although it has been used as a broad spectrum remedy in India for centuries and is referred to as the queen of Ayurveda, ashwagandha has only been intensively studied under laboratory conditions for a few decades. 
If you want to boost your energy levels, look younger and stay healthy, then ashwagandha might be the medicinal herb you are looking for. As you'll see in a moment, the health benefits of ashwagandha are impressive.
Ashwagandha is an adaptogenic medicinal plant popular in Ayurvedic medicine, which has shown very good results in lowering high blood lipids and in rebalancing hormone-related thyroid problems.
In India, ashwagandha is also used to boost the immune system.
Ashwagandha is also called Indian Ginseng because of its properties to increase stamina and reduce stress extremely effectively.
Here we are going to discuss the benefits of ashwagandha in healing the thyroid and adrenal glands, improving mood and energy levels, preventing cancer, and promoting brain health.
Ashwagandha is a superstar in improving thyroid health. Scientists don't know exactly how adaptogens work, but we do know that they can be extremely effective at re-establishing hormonal balance.
One of the most incredible aspects of an adaptogenic medicinal herb like Ashwagandha is that it can help people whose thyroid is out of whack. It has also been shown to help people with inflammatory symptoms in the thyroid, whose thyroid is no longer fully active, and people with an overactive thyroid.
Adaptogenic herbs work with the body to restore balance, whether it is low or high.
Animal studies have shown that ashwagandha restores the balance of thyroid hormones. In a 20-day study, mice were given ashwagandha and their T3 and T4 levels were analyzed along with lipid peroxidation (protection by antioxidants). Significant increases in serum T4 were found, indicating that this medicinal plant can help with decreased thyroid function.
Ashwagandha may also improve thyroid function as it greatly reduces lipid peroxidation by eliminating free radicals that cause cell damage. These results prove that ashwagandha can be useful in treating hypothyroidism.
There are millions of people suffering from thyroid problems right now (many don't even know it) and ashwagandha could be the solution they are looking for.
Ashwagandha has also been shown to be effective on adrenal function by helping with adrenal fatigue and chronic stress.
The adrenal glands are endocrine glands that are responsible for releasing hormones (cortisol and adrenaline) in response to stress on the body.
When the adrenal glands become overused due to excessive emotional, physical, and mental stress, it can lead to a weakened kidney condition. As can be seen in the table below, adrenal fatigue can also affect other hormones, including progesterone, which can lead to problems trying to have children and low DHEA levels, which in turn can accelerate the aging process.
Medical studies have shown that ashwagandha improves cortisol levels, increases insulin sensitivity, and naturally maintains hormonal balance. One study reported on the case of a 57-year-old woman with atypical changes in kidney tissue. She was treated with Ashwagandha for six months and after that she showed improvements on four adrenal hormone markers including corticosterone and 11-deoxycortisol, where there was decreases of 69 percent and 55 percent, respectively - a significant improvement! This hormonal improvement coincided with a noticeable decrease in hair loss.
Ashwagandha (Glycowithanolides) is a powerful antioxidant. Ashwagandha repairs oxidative damage caused by streptozotocin in rats. 
Ashwagandha's chemoprotective effects may be due to its antioxidant and detoxifying properties. 
Ashwagandha plays an antioxidant role in relieving kidney problems caused by oxidative stress. 
When taken once a day for 21 days, Ashwagandha increased superoxide dismutase (SOD), catalase, and glutathione peroxidase in rats. 
It was found that ashwagandha stimulates the activity of the immune system and increases the cell activity of the natural killer cells in mice. 
Ashwagandha extract supported the proliferation of lymphocytes, bone marrow cells and thyme cells in mice. 
Ashwagandha increased the Th1 cytokines and the stress-related reduced T cell population in chronically stressed mice. 
Ashwagandha suppressed myeloid suppressor cells (MDSC) and tumor-associated macrophages (TAMs). 
There is now clear evidence that ashwagandha can help treat anxiety and depression. One study even showed that the effects of the common pharmaceutical agents lorazepam and imipramine were comparable, but without their side effects. 
In a 12-week control study, 87 participants with anxiety were given 300 mg of ashwagandha extract or two placebo tablets twice a day. The group with the Ashwagandha treatment saw much greater improvements in anxiety, but also in concentration, they also showed less stress and less fatigue than the placebo group.
Another major benefit of Ashwagandha is the lack of undesirable reactions when taken, compared to antidepressants and anti-anxiety medications, which can have dire side effects.
Ashwagandha is used specifically as a tonic to calm the nerves (nerve tonic).
Ashwagandha extract could be helpful in the psychiatric treatment of anxiety. 
Highly concentrated Ashwagandha extract increased the resistance to stress in a safe and effective way and thereby resulted in an improved self-assessment of the quality of life in people. 
Ashwagandha resulted in a significant decrease in cortisol levels and a reduction in stress compared to a placebo.  Cortisol, the body's own stress hormone, contributes to muscle loss and weakness, wrinkles and cognitive disorders.
Ashwagandha extract improved audio-verbal working memory in individuals with bipolar behavior. 
Ashwagandha is a mood stabilizer for anxiety and depression and behavior in rats that was caused by social isolation.  
Ashwagandha extract was successful in treating behavioral disorder (OCD) in mice. 
Ashwagandha was shown to be effective in treating sleep problems and associated oxidative stress in mice. 
Ashwagandha had a significant stress-relieving effect in experiments with rats and the treated animals showed improved stress tolerance. 
Ashwagandha extract reduced chronic, stress-related stomach changes more successfully than the drug ranitidine, increased the sexual drive and cognitive impairments (rat experiments). 
Ashwagandha doubled swimming performance in rats and prevented the decrease in adrenal cortisol and ascorbic acid (during exposure to swimming).
Ashwagandha has a sleep-promoting effect through a GABAergic mechanism. 
Ashwagandha belongs to a subgroup of "Rasayanas" (or Elixir) known as "Medhya-Rasayanas" (Medhya refers to the mental and intellectual ability). 
Ashwagandha has a cognitive-promoting effect. It is helpful in children with memory problems and prevents memory loss in the elderly. 
Relaxation, brought about by the anti-stress effects of ashwagandha, also improves long-term visual memory. 
Ashwagandha (Withania sominifera glycoprotein) was shown to be effective against most of the phytopathogenic fungi and bacteria tested. 
Ashwagandha inhibited fungal growth by suppressing spore formation and hyphae growth.  Ashwagandha showed effective antifungal activities on Aspergillus flavus, Fusarium oxysporum and Fusarium verticilloides.
Ashwagandha is widely used to treat lung conditions. 
Ashwagandha showed antibacterial activity against Clavibacter michiganensis subsp. michiganensis .. 
Ashwagandha fought Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA). 
Ashwagandha extract inhibited the growth of the gram-negative Neisseria gonorrhoea. 
Oral ingestion of Ashwagandha extract successfully cured Salmonella infections in mice. 
Ashwagandha was shown to be effective in patients with acute viral liver disease. 
Ashwagandha was effective in cell cultures of the herpes simplex virus type 1 (HSV-1). 
Ashwagandha extract showed antiviral properties in cell cultures of infectious bursitis. 
Ashwagandha could help alleviate the neurocognitive disorders associated with HIV-1. 
Ashwagandha helps treat leishmaniasis. 
Ashwagandha extract is used to treat malaria. 
Ashwagandha showed an anti-parasitic effect on malaria-infected rodents. 
Studies have shown that ashwagandha extract has promising effects in the prevention and treatment of cancer. In certain studies, scientists found that Ashwagandha extract has an extremely effective anti-tumor effect. 
The extract helps suppress the spread of cancer cells, especially breast, lung, stomach and colon cancer cells, which are among the most common types of cancer in the world.
Ashwagandha is believed to prevent cancer cells from growing, primarily through its ability to boost the immune system and its antioxidant properties. Ashwagandha supplements are correlated to an increase in white blood cells, which in turn indicates that the immune system is better able to protect the body from disease and harmful influences. 
Another way ashwagandha can prevent cancer is by blocking the blood vessels around the cancer cells from supporting tumors from growing.
In addition to being able to inhibit the growth of cancer cells, studies have shown that ashwagandha, in conjunction with chemotherapy, can be very helpful in treating a pre-existing cancer.
Ingesting the extract seems to ensure that the immune system is not suppressed due to the chemotherapy. Ashawagandha can counteract one of chemotherapy’s biggest problems, a decrease in white blood cells, which makes cancer patients much more likely to get infected.
Many cancer experts now recommend Ashwagandha extract, both for preventing cell changes and as a support for traditional cancer treatments. In fact, studies have shown that when given only ashwagandha instead of other forms of treatment, symptoms even disappeared in some patients. 
Ashwagandha works against fatigue through pathological cell changes and also contributes to improving the quality of life.
Ashwagandha is an effective and relatively safe radio sensitizer or chemotherapeutic agent.
Ashwagandha increases the number of white blood cells (WBC) and their function, which is decreased in the chemotherapy treatment of cancer.
Ashwagandha increased the white blood cell (WBC) counts of paclitaxel-induced neutropenias (abnormally low levels of neutrophils) during chemotherapy.
Growths in breast tissue
Ashwagandha (withaferin A) inhibited the growth and cell migration of breast cancer cells in people.
Ashwagandha extract significantly reduced the number of cells that divide in breast cancer.
Ashwagandha (withaferin A) inhibited the activation of STAT3 in human breast cancer cells.
Tissue changes in the intestine
Ashwagandha (Withaferin-A) is effective for cell changes in the bowel area (suppresses Notch-1).
Alcohol extract from ashwagandha leaves inhibited the growth of altered intestinal cells by 98 percent.
Tissue changes in the brain
Ashwagandha leaves (Withaferin A, Withanon, Withanolide A) inhibit growth and differentiation in brain cells and help treat tissue changes.
Ashwagandha has an anti-cancer effect on neuroblastoma cells (IMR-32).
Cell changes in the stomach
Ashwagandha root (withanolide sulfoxide) prevents the growth of cells that can be responsible for tissue changes in the stomach in humans.
Ashwagandha has an inhibitory effect on tissue changes in the prostate.
Ashwagandha (Withaferin A) suppresses tumor proteasomes in human prostate cancer cell cultures.
Ashwagandha has been shown to be effective against urethane-induced lung tissue changes in mice.
Ashwagandha (withaferin A) prevented growth and cytotoxic activity in human cell lines that can cause tissue changes in the lungs (NCI-H460).
Changes in kidney tissue
Ashwagandha (Withaferin A) prevented the growth of human cells, which can be the cause of changes in kidney tissue.
Changes in skin cell growth
Ashwagandha caused the death of melanomeric cells in humans (through the formation of ROS).
Ashwagandha was effective in treating cell changes in the head and neck.
Long-term treatment with ashwagandha brought skin changes under control.
Ashwagandha has been shown to be effective in preventing skin cell changes in animals exposed to UVB radiation.
Ashwagandha (withaferin A) prevented the activation of genes associated with skin changes.
Ashwagandha (Withaferin A) showed an inhibitory effect on cell changes in the pancreas.
Cell changes on the cervix
Ashwagandha (Withaferin A) is effective in treating and preventing cervical discomfort.
Ashwagandha can protect the nervous system
Ashwagandha (metabolites of the constituents) promotes nerve growth when taken for seven days.
Ashwagandha promotes the formation of dendrites.
Ashwagandha is also effective for neuromuscular coordination.
Ashwagandha plays a potential neuroprotective role in acute stress in rats.
Ashwagandha root could help with a disturbed movement sequence.
Ashwagandha caused neurite dilation in normal and damaged cortical nerve cells.
Ashwagandha was effective in scopolamine-induced memory loss in experiments with mice and with brain cell cultures.
Ashwagandha was found to be useful for ailments associated with loss of cognitive abilities.
There are various studies that show that ashwagandha prevents, reverses, or eliminates the loss of nerve connections.
Ashwagandha and neurodegenerative complaints
Ashwagandha reversed behavioral deficits and the side effects seen in trials with neurodegenerative problems.
Ashwagandha (Withanoside IV), when taken orally, may reduce neuronal dysfunction.
Ashwagandha and nerve changes
Ashwagandha ameliorates catecholamines, oxidative damage, and physiological abnormalities observed in brain disorders studies in mice.
The Ashwagandha extract brought about an improvement in the behavior as well as the anatomical and biochemical malformations in mice with brain changes that are associated with movement disorders.
Ashwagandha and Hereditary Brain Changes
Ashwagandha has a neuroprotective effect on behavior, biochemical and mitochondrial dysfunction in an animal experiment on hereditary changes in the brain.
Ashwagandha and behavioral problems
Ashwagandha is effective for highly behavioral people.
A herbal combination preparation with ashwagandha can cause alertness and impulse control in children. The effect of pure ashwagandha is still unclear.
Ashwagandha promotes heart health
Ashwagandha components have been shown to have beneficial "invigorating" effects on the heart.
Ashwagandha treatment has been shown to increase heart rate and promote contractility and relaxation.
Ashwagandha lowers blood pressure (by automatically blocking the ganglia).
Ashwagandha has a profound effect in lowering cholesterol and preventing the arteries from hardening.
Ashwagandha powder shows a significant decrease in triglycerides (31.25% to 44.85%) in rats with high cholesterol when ingested 0.75 to 1.5 grams per day.
It has been shown in various experiments that Ashwagandha protects the heart from stress and damage.
- Ashwagandha improved cardiorespiratory endurance in top athletes.
- Ashwagandha protected against oxidative damage from isoprotenalin-induced (ISO) myocardial infarction in rats.
- Ashwagandha extract protects the heart from the toxicity caused by doxorubicin.
- Ashwagandha shows a protective effect on vascular problems in rats.
- Ashwagandha has been shown to have a protective effect on isoprotenaline-induced cardiovascular changes in rats.
- The highest effectiveness has been shown in rats in the functional restoration of the heart with a dose of 50 mg / kg.
- Ashwagandha supplements with milk are recommended in the treatment of stress-related cardiovascular ailments.
Ashwagandha is an anti-diabetic drug
Ashwagandha improves blood and urine glucose, glycohemoglobin (HbA1C) and liver enzymes in rats with impaired metabolism.
Ashwagandha root can cause low blood sugar in people with sugar digestion problems.
Ashwagandha together with the "Shilajit" extract significantly reduced the symptoms associated with sugar digestion problems, the average blood sugar values during fasting and the cholesterol level in test subjects.
Ashwagandha lowers the blood sugar level in rats with type II diabetes, prevents excessive insulin values and improves glucose tolerance.
Ashwagandha ameliorated diabetes-induced testicular dysfunction in prepubescent rats.
Ashwagandha has been shown to have effective properties in rendering free radicals harmless and helps to improve the antioxidant status of rats with impaired sugar utilization.
Withaferin A is partly responsible for these effects.
Ashwagandha reduces pain and lowers the body temperature.
Ashwagandha is a pain reliever that has a calming effect on the nervous system in the event of pain reactions.
Ashwagandha (1000 mg / kg / orally) produced significant pain relief in an experiment with rats on a hot plate.
Ashwagandha also has an antipyretic effect.
Ashwagandha for women
Ashwagandha relieves symptoms of hormonal fluctuations. It stimulates the endocrine glands and supports the regulation of hormone release during phases of increased hormone change.
Ashwagandha is also effective in reducing symptoms such as hot flashes, mood swings, and anxiety.
Ashwagandha extract stimulates thyroid activity and promotes anti-peroxidation of liver tissue.
Ashwagandha relaxes the psyche, relieves anxiety and thereby stabilizes the mood
Patients with behavioral disorders including mood swings that are hormone-related.
Discomfort of the female body
Ashwagandha was one of the components of a multi-herbal Ayurvedic preparation called "Testo" (at a concentration of 25 mg) that provided significant relief in patients with complaints of the female genital organs.
Ashwagandha can act as a missed menstrual treatment.
Control of tissue changes in the female body
Long-term treatment with ashwagandha regulates benign growths that develop in the muscular walls of the uterus.
Ashwagandha increases the chance of getting pregnant
Ashwagandha has been used to treat fertility disorders in male mice.
Ashwagandha can help restore hormone balance and increase fertility through relaxation and stress relief.
Ashwagandha increases lutropin (LH) hormone levels to normal levels in infertile men.
Testosterone (T) levels increased in infertile individuals after treatment with ashwagandha.
Ashwagandha improves the functioning of the thyroid gland, which is responsible for regulating reproductive hormones.
Ashwagandha is effective in treating men with hormone-related problems of the sex glands.
Ashwagandha is also effective in restoring male fertility. It improves semen quality and sex hormones in men.
Taking Ashwagandha (Withania somnifera) for 60 days significantly improved the weight of the testicles and additional sexual organs in male rats.
Ashwagandha is effective in restoring sperm in mice.
Ashwagandha has been shown to fight the formation of ROS (reactive oxygen species) in infertile men.
Ashwagandha extract was effective in increasing sexual performance in male rats.
Ashwagandha is one of the best antidotes (due to its herbal medicinal properties) for arsenic-induced reproductive toxicity in male rats.
Ashwagandha is also effective on semen metabolites in infertile men.
Ashwagandha, however, showed no psychological improvement in men with erectile dysfunction.
Ashwagandha for male infertility
Ashwagandha (Withania somnifera Dunal) is traditionally used in Ayurvedic medicine as an aphrodisiac to treat male sexual dysfunction and infertility.
Studies support the belief that it increases testosterone levels in humans. Experiments have also shown that ashwagandha can induce spermatogenesis in rats.
Men and women alike suffer from the burden of human infertility, although the etiology is unknown in about half of infertile men. However, the main cause of reduced fertility is oligospermia. 1
In addition, many men with sexual dysfunction undergo alternative therapies, creating a need for agents that are both safe and effective. Using ashwagandha for its beneficial effects on stress and mental health, as well as influencing certain basic male infertility problems, could have significantly beneficial effects on couples facing infertility.
A 90-day pilot study conducted in infertility centers in Mumbai, India, involved 46 men between the ages of 22 and 40 who suffered from oligospermia (with a sperm count> 20 million sperm per ml of semen).
All men had a history of regular sexual relations with a healthy partner who did not suffer from infertility. The men were randomly assigned to treatment with the full range of Ashwagandha extract and received 225 mg three times a day per dose; the comparison group received placebo capsules three times a day. At the end of the treatment, sperm parameters and serum hormone levels were measured.
At the end of 90 days of treatment, the men who received ashwagandha were found to have:
- 167% increase in sperm count
- 53% increase in sperm volume
- 57% increase in sperm motility
- 17% increase in serum testosterone levels
All improvements were statistically significant compared to minimal improvement in all scores in the placebo group. Almost 70% of the Ashwagandha group described the therapy as “excellent” compared to 12% of the placebo group.
The scientists came to the following conclusion: "The results of the current study provide evidence of the safety, effectiveness and tolerability of treatment with Ashwagandha extract."
Ashwagandha reduces immune system diseases
Ashwagandha powder has a preventive effect on mice with systemic lupus erythematosus (SLE).
Ashwagandha powder reduces inflammation in pristan-induced systemic lupus erythematosus.
Ashwagandha promotes bone health
Ashwagandha stimulates bone formation and is also a means of building bones.
Ashwagandha supplements improved calcium retention and bone calcification.
Ashwagandha had positive and no adverse effects on tibial calcium and phosphorus levels in laying hens.
Ashwagandha leaves prevented bone loss in mice (both by inhibiting resorption and by stimulating new bone formation prior to the onset of osteoporosis).
Ashwagandha extract had a protective effect on adjuvant-induced arthritis in rats.
Ashwagandha improved bone calcification in calcium-deficient rats without ovaries.
Ashwagandha suppressed gouty arthritis in rats.
Ashwagandha root extract has bone protective effects in osteoarthritis.
Hormonal Effects of Ashwagandha
Follicle stimulating hormone
- an increase in the overall mean FSFI score, indicating a significant improvement in the FSD
- the mean excitation and lubrication ranges of FSFI were significantly increased compared to the placebo group
- a significant improvement in both orgasm and sexual satisfaction
- VO2max had increased by 4.91% after eight weeks and by 5.67% after 12 weeks.
- The measured values of the quality of life (QOL) were also positively influenced with 9.46%, from the baseline value by 7.6% and sub-areas of physical well-being from the baseline value.
- Environmental impacts on QOL were also significantly higher at the end of the study.
- No changes were observed in basic parameters such as heart rate, blood pressure, or breathing at rest.
- All changes were statistically significant compared to the placebo group.
- 22% decrease in the mean serum cortisol level
- 3% weight loss compared to only 1.4% in the placebo group
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- Agarwal R, Diwanay S, Patki P, Patwardhan B. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. J Ethnopharmacol. 1999 Oct; 67 (1): 27-35.
Testosterone (T) levels in infertile individuals increased after treatment with ashwagandha.
Ashwagandha works as an anti-estrogen in human breast cancer cells, but this is not necessarily the case with normal cells.
Ashwagandha caused the luteinizing hormone (LH) to rise to normal levels in infertile men.
Follicle-stimulating hormone (FSH) levels increased in infertile men after treatment with ashwagandha.
Ashwagandha stimulates thyroid hormone function in female mice.
Ashwagandha can only increase T4 (thyroxine) levels in female mice.
Ashwagandha extract stimulated thyroid activity in adult male mice.
Ashwagandha improved metformin-induced hypothyroidism in mice with type II diabetes.
Ashwagandha is an effective treatment for hypothyroidism when taken for 20 days.
Ashwagandha also prevents goiter (an enlarged thyroid gland) from forming.
Ashwagandha protects the liver
Ashwagandha significantly increases the bile acid content of the liver in rats with high cholesterol levels.
Ashwagandha lowered liver enzymes in metabolism (glucose-6-phosphatase), glycogen and brought them back to normal levels in alloxane-induced rats with diabetes.
Ashwagandha prevents liver toxicity disorders induced by ionizing radiation in rats.
Ashwagandha protects the rat liver against heavy metals.
Ashwagandha is good for the gut
For intestinal ulcers, irritable bowel syndrome and rectal bleeding, enemas with ashwagandha extract are prescribed.
Ashwagandha root extract restores the mucous membrane of rats with inflammatory bowel disease (IBD).
Ashwagandha prevents constipation.
Ashwagandha is used in the prevention and treatment of hemorrhoids (swollen veins around the anus or rectum).
Ashwagandha protects the pancreatic cells
Ashwagandha (Withaferin A) could be used as supportive treatment to improve the outcome of a pancreas transplant.
Ashwagandha protects against pancreatic cell damage in rats with type II diabetes.
Ashwagandha protects the kidneys
Ashwagandha extract protects the kidneys from gentamycin-induced toxicity.
Ashwagandha effectively cured kidney corpuscles for carbendazim-induced damage.
Ashwagandha prevents respiratory diseases
Purified polysaccharides from Ashwagandha have a cough-relieving effect in guinea pigs.
Two teaspoons of ashwagandha three times a day ensure a quick recovery from bronchitis.
Ashwagandha for the skin
Ashwagandha (a paste made from cooked leaves) is widely used to heal wounds, scabies, ringworm, leukoderma, leprosy, and acne.
Ashwagandha (Withaferin A) prevents white spots on the skin (avoiding the risk of skin hypopigmentation).
Ashwagandha extract caused the skin to darken in melanophores in the wall lizard.
Ashwagandha can reduce addiction to morphine
Ashwagandha can help reduce addiction to morphine.
Ashwagandha suppressed jumps in morphine withdrawal symptoms - a sign of the development of morphine addiction.
Ashwagandha for genetic diseases
Ashwagandha was shown to be effective in treating the genetic disease “adrogenital syndrome” (excessive growth of the adrenal gland) in a 57-year-old woman.
Ashwagandha is also effective in treating symptoms of Down syndrome.
Ashwagandha supports muscle growth
A significant increase in body weight was observed in rats treated with Ashwagandha compared to the control group.
Ashwagandha supplements produced significant increases in muscle mass and strength in young men and could be useful in conjunction with resistance training.
Ashwagandha was effective in treating patients with sarcopenia (the loss of muscle mass and strength due to the aging process).
Ashwagandha appears to be risk-free and strengthens muscle activity.
Ashwagandha for longevity
Ashwagandha leaf extracts (i-extract) have anti-aging properties.
It is also said to have strong aphrodisiac, rejuvenating and life-prolonging properties.
Ashwagandha prevents seizures
Ashwagandha has been used to treat seizures for centuries.
Ashwagandha suppressed seizures caused by PTZ (pentetrazole) in animals deprived of ethanol.
Ashwagandha is also a component of the "Siotone" granules, which offer significant protection against seizures caused by pentetrazole, severe electric shocks and strychnine.
Ashwagandha reduces age-related cataracts
Ashwagandha can slow down the formation of cataracts in cells.
Ashwagandha plant extract also prevents “diabetic cataracts” caused by chronically high blood sugar levels.
Ashwagandha offers optimal protection against selenite-induced, oxidative lens damage.
Ashwagandha is widely used to treat conjunctivitis.
Ashwagandha protects against industrial toxins
Ashwagandha leaf extract protects normal human cells from the toxicity of methoxyacetic acid (an essential industrial metabolite).
Ashwagandha has also been shown to be effective against diesel fumes, heavy metals, and pesticides that damage the body's various organ systems.
The effect of ashwagandha on blood cells
Ashwagandha (Withaferin A) causes suicidal blood cell death.
Ashwagandha (the leaves) successfully cured anemia, a common disease among Indian women in rural areas.
Ashwagandha also has the potential to increase red blood cells.
Ashwagandha extract has been shown to increase the number of white blood cells. Injection of ashwagandha with milk resulted in an increase in white blood cells in animals with low levels.
Ashwagandha is an effective antiserum
External application of the plant extract acts as an antidote to snake bites in rural parts of India.
A purified glycoprotein from Ashwagandha inhibited the hyaluronidase of the poisons of the cobra (Naja Naja) and the viper (Daboi russelii).
Ashwagandha root in combination with other remedies are prescribed against snake venom and scorpion stings.
Ashwagandha along with aloe vera lowered blood sugar levels in mice with diabetes caused by streptozotocin (STZ).
Ashwagandha acts synergistically with diazepam in the protection against isolation-induced behavior in rats.
Ashwagandha works in conjunction with Vitamin D (1,25 (OH) 2 D3) to promote calcium retention and bone calcification.
A combination of glucan obtained from the maitake mushroom and ashwagandha extracts has powerful biological effects on a healthy immune system and stress relief.
Ashwagandha combined with anti-tuberculosis drugs and chyawanprash (a herbal supplement made from many natural ingredients) were effective in treating pulmonary tuberculosis.
The Ashwagandha root is considered a tonic, aphrodisiac, narcotic and diuretic, it has an anti-parasitic, astringent, thermogenic and stimulating effect. It is an important component in more than 200 formulations of traditional medicine such as Ayurveda, Siddha and Unani.
The leaves taste bitter and have a characteristic odor. They are recommended for fever and painful swellings.
The flowers have an astringent, cleansing, diuretic and aphrodisiac properties.
The seeds contain an anti-parasitic agent.
In Ayurveda, berries and tender leaves are prescribed, which are then applied externally to tumors, tuberculous glands, carbuncles and ulcers.
Other beneficial ingredients are the stems, fruits and the bark.
Active chemical components
The biologically active chemical components are alkaloids (Isopelletierin, Anaferin), steroid lactones (Withanolide, Withaferine).
Other components are saponins (sitoindoside VII and VIII) and withanolides (sitoindoside IX and X).
Ashwagandha is also known for structuring a wide range of secondary, low molecular weight metabolites such as terpenoids, flavonoids, tannins, phenols, and resins.
The leaf extract contains carbohydrates, glycoside sugars, proteins and amino acids. It is also an abundant source of iron.
Ashwagandha Dosage and Ingestion
A typical dose of ashwagandha is 3-6 grams of the dry root or 300-500 mg of the extract daily. The best effect is achieved with regular use over several months.
In addition, recipes such as a mild brew, an alcoholic extract mixed with butter fat or honey or oil are effective for external use.
Ashwagandha extract was risk-free in rats given up to 1,500 mg per kilo orally for 6 months.
Ashwagandha extract of 2,000 mg per kilo of body weight, which was taken daily, did not show any negative effects in rats and can therefore be classified as non-toxic.
Ashwagandha side effects
Ashwagandha is generally safe and has no side effects when taken at the recommended dosage. Large amounts of ashwagandha powder can cause abdominal pain and diarrhea.
Ashwagandha should not be used during pregnancy as high amounts can cause miscarriage.
Because ashwagandha acts as a mild sedative on the brain, patients should avoid alcohol, sedatives, and other anti-anxiety drugs while taking ashwagandha.
As ashwagandha can affect thyroid hormones, people with hypothyroidism should only take ashwagandha under medical supervision, as the dosage of the medication may have to be adjusted.
Ashwagandha and the brain
Emotional, physical, and chemical stress can damage the brain and nervous system. Recent research has shown that ashwagandha is more than just a stress reliever; it also protects the brain from degeneration and mitigates the effects of Alzheimer's, depression and anxiety.
One of the main reasons ashwagandha is so effective at healing the brain is because of its powerful antioxidants that destroy free radicals that are responsible for the aging process. A study published in the scientific journal Phytotherapy Research explains these benefits:
“Several studies have shown that natural antioxidants such as vitamin E, vitamin C and beta-carotene can help destroy free radicals that can aid in the onset and progression of [Alzheimer's disease. But we found that the inhibitory effect of lipid peroxidation was more effective than that of other commercially available antioxidants. "
Scientists at the National Brain Research Center found that mice with Alzheimer's were unable to retain what they learned, but significant improvement was seen after 20 days of treatment with the ashwagandha supplement. The results of this study showed a reduction in amyloid plaques (which cause brain degeneration).
Ashwaganda for perseverance and perseverance
Studies have shown that ashwagandha can increase endurance in physical activity by increasing brain function and reducing physical pain. Thanks to the positive, calming and at the same time energy-boosting effect on the brain and the ability to reduce stress hormones, improved concentration, motivation and stamina have been observed when giving Ashwaganha.
A specific study showed that laboratory rats given ashwagandha could swim twice as long as the same type of rat given no supplement.  Scientists believe that similar effects are seen in humans due to the extract's ability to balance adrenal hormones that play a role in physical activity.
The extract also had a pain relieving effect on muscles and joints, while at the same time keeping energy levels steady; another reason to believe that this could be a promising supplement for athletes or for those struggling to be physically active due to pain.
Ashwagandha promotes telomerase activity
Ashwagandha (Withania somnifera Dunal) has been used in Ayurveda for thousands of years as "Rasayana" or "life extender". Scientists are investigating ways to extend a healthy life while studying some physiological factors that could accelerate the aging process, particularly the breakdown of telomeres.
While ashwagandha is believed to be able to extend lifespan, there is limited scientific evidence to support this claim. Could ashwagandha’s effectiveness in slowing the aging process be due in part to its ability to promote telomerase activity?
The shortening of telomeres as we age is well known, while telomerase, which is needed to maintain the length of telomeres through replication, is essential for a healthy life.1 Various factors including stress accelerate the aging process by shortening telomeres.2
Because ashwagandha has stress relieving properties, its ability to increase telomerase activity suggests that it may indeed act as a "life extender" by supporting natural bodily processes.
Human HeLa cells were stored in the nutrient medium DMEM and supplemented with 10% fetal calf serum in a humidified incubator. The cells (40% - 60% confluence) were treated with different concentrations - 10 μg, 50 μg, 100 μg, 500 μg, 5 mg - Ashwagandha extract. The cells were collected and centrifuged and assayed for telomerase activity and analyzed using the polymerase chain reaction quantification of the activity of the enzyme telomerase (TRAP method).
Result of the study:
Ashwagandha extract at a concentration of only 10 μg to 50 μg increased telomerase activity by 45% after 72 hours of exposure.
A dose-dependent increase in telomerase activity of up to 50 μg / ml could be observed, after which the activity began to decrease, since the preparation is a powder suspension.
Telomerase activity was highest between 50 ng and 5 μg total protein cell extract, with 2 μg being the ideal protein concentration in this study.
Scientists came to the following conclusion: "Ashwagandha extract can promote telomerase activity", and they propose an evaluation of various incipient disease states in adults to analyze the holistic protective effect.
Ashwagandha and Sexual Disorders in Women
Many women suffer from sexual dysfunction with problems with orgasm and sexual intercourse. Ashwagandha (Withania somnifera) has traditionally been used in Ayurveda as an adaptogen to protect the body from stress and treat sexual dysfunction in both men and women.
Can taking a highly concentrated Ashwagandha extract alleviate female sexual dysfunction (FSD) by reducing stress or by reversing androgen deficiency syndrome?
Sexual dysfunction (FSD) is thought to affect up to two-thirds of all women, and it mainly affects women who have emotional or stress-related problems. 1
Furthermore, little is known about the causes and treatment options are insufficient, although a multi-faceted approach appears to be the best solution.2 In this study, ashwagandha combined with therapy reduced stress and increased testosterone levels, factors that both cause FSD could. However, the scientists found that ashwagandha should not be considered an aphrodisiac because the supplement did not affect sexual desire.
A randomized double-blind pilot study with a placebo control group was carried out in the "Trupti Hospital" and the "Santati Fertility Center", Thane in Maharashtra, India. A total of 50 women between the ages of 21 and 50 who had been in a stable heterosexual relationship for over a year and who had been diagnosed with female sexual dysfunction (FDS) were given and took 300 mg of ashwagandha or a placebo supplement twice daily for eight weeks also take part in a counseling program.
Sexual function was assessed using two psychometric scales: the Female Sexual Function Index (FSFI) questionnaire and the Female Sexual Distress Scale (FSDS), as well as the total number of intercourse and the number of successful sexual experiences.
Result of the study:
After eight weeks, women who received ashwagandha had:
There was no difference in sexual activity between the two groups, but there was a significant improvement in sexual intercourse in the treated group after eight weeks.
The scientists concluded: "Ashwagandha extract could be helpful in treating FSD and the lack of undesirable effects indicates that the extract is safe to consume."
Ashwagandha for cardiorespiratory resilience
Ashwagandha is a well-known adaptogen and is valued for increasing vitality, energy, stamina, and stamina, suggesting that it could improve physical performance. The question arises as to whether a high concentration of Ashwagandha extract can promote cardiorespiratory resilience and improve the quality of life (QOL) in healthy, sporty adults.
Since adults would like to get better results in their sporting activities, an improvement in VO2max, or the maximum oxygen uptake of the body, which can be used during training, ensures better muscle effectiveness and performance.1 Furthermore, the values of the quality of life are decisive for sporting Exercise improves both physical and mental measurements. 2
Ayurvedic recipes, also known as Rasayana, such as Ashwagandha were used as a remedy for general weakness as well as to improve vitality and stamina; however, research was needed to demonstrate clinical effectiveness.
The study shows that ashwagandha increases both cardiorespiratory resilience and quality of life in healthy, sporty adults.
A prospective, randomized, double-blind trial was carried out with a placebo control group in “Hyderabad Spine Clinics”, Secunderabad, India. A total of 50 healthy adults between the ages of 20 and 45 with a normal body mass index (BMI) received 300 mg of ashwagandha twice daily or a placebo for 12 weeks.
The effectiveness was carried out by a 20-minute shuttle run test from the initial value, week 8 and week 12, with the determination of the oxygen consumption during the highest physical performance (VO2max) and a self-assessment of the quality of life through the questionnaire of the "World Health Organization-QOL ".
During the course of and at the end of the study, the following were found in adults taking ashwagandha:
The scientists found: "Highly concentrated broad spectrum Ashwagandha extract improves a person's resistance to stress and thereby at the same time improves the self-assessment of quality of life."
Link Between Stress and Weight Control
Ashwagandha (Withania somnifera Dunal) has a long history of use as an adaptogen and helps combat the negative effects of stress on the body. Various bioactive substances in Ashwagandha have been shown in preclinical studies to affect cortisol levels and have anxiolytic properties.
Since previous research showed a link between stress, anxiety and weight gain, the question arose whether ashwagandha extract would improve general well-being and reduce physiological stress markers associated with obesity, as well as curb appetite and reduce stress-related eating behaviors influencing weight and increasing general well-being.
A third of all adults say they live under extreme stress, and almost half of all adults say, according to the American Institute of Stress, that stress has increased in recent years. Chronic stress has been linked to adverse health effects on the heart, brain, and immune system1 and, more recently, weight gain.
In fact, the results of a study published in February 2017 show that in over 2,500 men and women, those who had the highest levels of the stress hormone cortisol had a larger waist circumference, and a higher weight and BMI; obese people showed a particularly high level of cortisol. 2
Using a natural solution such as ashwagandha extract to mitigate the stress-weight relationship by controlling cortisol levels could have a significant impact on health care costs and personal happiness.
An eight-week prospective clinical study at the study center in Pune, India, examined 52 men and women between 18 and 60 years of age who had a value on the "Perceived Stress Scale (PSS)" above 20, which indicates chronic stress symptoms, as well as a body Mass index (BMI) between 25 and 39.9.
It was a randomized, double-blind trial with a control group and the administration of placebos. The subjects received a broad spectrum ashwagandha extract at a dose of 300 mg twice daily or placebo tablets twice daily.
Primary results were measured with the PSS value and the “Food Cravings Questionnaire-Trait (FCQ)” and secondary results were related to weight, BMI, serum cortisol levels and feelings of happiness.
At the end of the eight weeks, people who received ashwagandha had the following results:
In the primary result and as measured by the PSS value, people who took Ashwagandha showed a marked reduction in the mean value, which fell from 20.3 to 13.6, which was a significantly greater improvement compared to the placebo group.
The FCQ averages for planning, positive reinforcement, negative reinforcement, lack of control, emotion, and environment had all decreased statistically significantly in the Ashwagandha group, indicating that subjects refused to use food as a method of coping with stress.
The scientists came to the following conclusion: "Ashwagandha extract can help patients who are under chronic stress with weight control."
Ashwagandha studies and references
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